GH101:
Genetic Susceptibility to Chronic Disease​

Three chronic disease conditions which severely impact society in terms of morbidity, mortality and economic impact are cardiovascular disease (CVD), end stage renal disease (ESRD) and endothelial syndrome or atherosclerosis. Evidence has accumulated about the association between inflammation, oxidative stress and proinflammatory cytokines in these three disorders.  While atherosclerosis was originally considered a disease caused by impaired lipid storage, it has since been convincingly demonstrated that it is a result of misguided inflammatory processes. “Current evidence supports a central role for inflammation in all phases of the atherosclerotic process” (Libby, 2002).

As there is not yet any recognized, or even proposed, treatment for ESRD patients with chronic inflammation, it would be of obvious interest to study the long‐term effect of various anti‐inflammatory treatment strategies on the nutritional and cardiovascular status as well as outcome in these patients (Stenvinkel, 2002).